Acute septic arthritis after kidney transplantation due to Acremonium.

Sir, Fungal infections in renal transplant recipients are relatively rare, occurring mainly in the first 6 months post-transplantation. They are mainly due to Candida and Aspergillus [1]. We report the first case of acute septic arthritis due to Acremonium after kidney transplantation. Case report. A 57-year-old man was transferred to our hospital for acute arthritis of the right knee. His medical history included coronary artery disease treated by angioplasty and an aorto-bifemoral endovascular prosthesis in 1989. Dialysis was started in 1995 because of nephroangiosclerosis. He received a kidney transplant in October 1996. The immunosuppressive regimen included tacrolimus, azathio-prine and steroids, without induction therapy. He developed no impaired glucose tolerance. Twenty-eight months after transplantation, he was hospitalized for arthritis of the right knee. He had no fever, but the C-reactive protein level was 76.5 mgul. Arthrocentesis of the right knee yielded cloudy, yellow fluid with 5000 white blood cellsumm 3 (100% poly-nuclear cells). No infectious agent was revealed by Gram staining and no crystals were detected. Acremonium species grew on mycobacterial cultures of the synovial fluid and on blood cultures after 21 days. No cutaneous involvement of the fungus could be determined. Echocardiography and Doppler ultrasound examination of the dialysis fistula failed to reveal any mycotic aneurysms. The patient was treated with 350 mg intravenous (i.v.) liposomal amphotericin B. Because of acute kidney failure this treatment was stopped and replaced by 180 mguday amphotericin lipid complex IV combined with 600 mguday oral itroconazole. The patient needed dialysis three times. Clinical and infectious parameters improved and blood cultures for mycobacteria became negative. The creatinine level returned to 130 mmolul and itroconazole was continued for 3 weeks. One month later, after withdrawal of itroconazole, recurrence of fungal infection in the right knee was diagnosed. No localization was found on CT scan of the aorto-bifemoral prosthesis. The patient was successfully